Medicina Interna

La Medicina Interna es la disciplina médica principal en la cura de los adultos con una o varias enfermedades agudas o crónicas complejas. Los grandes ámbitos de actuación son el/la paciente crónico complejo, paciente agudo, apoyo unidades médicas y quirúrgicas, manejo de enfermedades multiorgánicas y el diagnóstico y manejo de cuadros sindrómicos mal definidos y enfermedades minoritarias. Nuestro Servicio de Medicina Interna gestiona 1.300 altas anuales, 1.100 interconsultas hospitalarias y 800 primeras visitas a consultas externas. Los principales GRD son los cuadros infecciosos, la insuficiencia cardíaca y la enfermedad tromboembólica venosa y hay que mencionar también por su idiosincrasia las enfermedades sistémicas-autoinmunitarias.

De este entorno surge el tipo de investigación en la que nos sentimos implicados, básicamente clínico-epidemiológica para conocer mejor los factores de riesgo, el diagnóstico, el tratamiento y el pronóstico de las patologías que asistimos.

Actualmente la plantilla está compuesta de 14 Facultativos con plaza y 7 médicos/eses Residentes. La mayoría de ellos y ellas con interés e implicación en la investigación.

Principales líneas de investigación

Enfermedad Tromboembólica Venosa
Enfermedades Infecciosas: COVID-19, SIDA, ETS, Tuberculosis, IRAs/Neumonía.
Insuficiencia Cardíaca
Enfermedades autoinmunitarias-sistémicas.

Objetivos estratégicos

Investigación clínico-epidemiológica
Participación en Registros Nacionales
Participación en Ensayos Clínicos fases II-III
Desarrollo de Tesis Doctorales

Publicaciones

Medicina Interna

Barca-Hernando M, Otalora-Valderrama S, Lopez-Nuñez JJ, Portillo-Sanchez J, Pagan-Escribano J, Lopez-Miguel P, Mahe I, Mena-Muñoz E, Jou-Segovia I, Imbalzano E, Agudo-de Blas P, Lorenzo-Hernandez A, Diaz-Pedroche C, Aibar-Gallizo J, de la Red-Bellvis G, Del Molino-Sanz F, Amado-Fernandez C, Fernandez-Reyes JL, Villalobos-Sanchez A, Lopez-Saez JB, Diaz-Brasero AM, Marcos-Jubilar M, Meireles J, Marchena-Yglesias PJ, Diaz-Peromingo JA, Marin-Romero S, Elias-Hernandez T, Andrade-Ruiz HA, Mehdipour G, Bikdeli B, Jara-Palomares L

Occult cancer in patients with unprovoked venous thromboembolism: Rationale, design, and methods of the VaLRIETEs study and the SOME-RIETE trial.

AMERICAN HEART JOURNAL, 2025, 284, 81-93 dx.doi.org/10.1016/j.ahj.2025.02.004

Medicina Interna

Mendoza-Zambrano E, Ballaz-Quincoces A, Lobo JL, Gomez-Cuervo C, Lopez R, Marchena-Yglesias PJ, Fernández C, Lopez-Miguel P, Jimenez D, Francisco-Albesa I, Alfonso M, Pedrajas-Navas JM, Lumbierres-Burgues M, Núñez-Ares A, Aibar-Arregui MA, Rodriguez-Matute C, Lopez-Saez JB, de Miguel-Díez J, Perez-Pinar M, Barca-Hernando M, Klok FA, Monreal M, Andrade-Ruiz H, González-Acosta M, Otero-Candelera R, Jara-Palomares L

Identification of phenotypes and predictors for dyspnea, echocardiographic probability of pulmonary hypertension, and confirmed CTEPH in patients with acute pulmonary embolism: Analysis of two large patient cohorts.

THROMBOSIS RESEARCH, 2025, 252, 109379-109379 dx.doi.org/10.1016/j.thromres.2025.109379

Medicina Interna

Brito-Zerón, P, Flores-Chávez, A, Garcia, LTD, Rouco-Esteves-Marques, R, Sáez-Comet, L, Sanchez-Berna, I, Gallego, LP, Perez-Quintana, M, Mozo, AN, Mascaró, O, Fonseca-Aizpuru, E, Guerrero, MB, Urbistondo, MM, Franco, RA, Rodriguez, PM, Escalante, B, Pasquau, F, Ferrando, MF, Anducas, NV, González, BM, Ramos-Casals, M, Montalvo, MA

FREQUENCY AND PATTERNS OF COEXISTENCE OF OTHER SYSTEMIC AUTOIMMUNE DISEASES IN PATIENTS WITH MIXED CONNECTIVE TISSUE DISEASE: IDENTIFICATION OF CLINICALLY RELEVANT SUBTYPES THROUGH CLUSTER ANALYSIS

ANNALS OF THE RHEUMATIC DISEASES, 2025, 84 dx.doi.org/10.1136/annrheumdis-2025-eular.A2009

Medicina Interna

Brito-Zerón, P, Garcia, LTD, Flores-Chávez, A, Herranz-Pérez, JC, Hidalgo, PS, Sanchez-Berna, I, Gea, JP, Perez-Quintana, M, Robles, EM, Mascaró, O, Fonseca-Aizpuru, E, Guerrero, MB, Urbistondo, MM, Ramirez, M, Marcos, M, Escalante, B, Pasquau, F, Jiménez, I, Anducas, NV, Bonías, MA, Ramos-Casals, M, Montalvo, MA

A NOVEL AGE-DEFINED PHENOTYPIC LANDSCAPE IN MIXED CONNECTIVE TISSUE DISEASE: DISTINCT CLINICAL AND IMMUNOLOGICAL PATTERNS AT DIAGNOSIS IN 211 SPANISH PATIENTS

ANNALS OF THE RHEUMATIC DISEASES, 2025, 84 dx.doi.org/10.1136/annrheumdis-2025-eular.B3557

Medicina Interna

Nopp S, Spielvogel C, Bikdeli B, Alberich-Conesa A, Hernández-Blasco L, Peris ML, Otero R, Jiménez D, Monreal M, Ay C

A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism.

SCIENTIFIC REPORTS, 2025, 15, 32744-32744 dx.doi.org/10.1038/s41598-025-14893-1

Medicina Interna

Hoberstorfer T, Nopp S, Steiner D, Hernández-Blasco L, Jou I, López-Núñez JJ, Fidalgo Á, López-Miguel P, Monreal M, Ay C

External validation of the VTE-PREDICT score for predicting recurrence and bleeding in venous thromboembolism: Results from the RIETE registry.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2025, 23, 3909-3919 dx.doi.org/10.1016/j.jtha.2025.08.007

Medicina Interna

Garcia, LTD, Flores-Chávez, A, Szántó, A, Priori, R, Bootsma, H, Armagan, B, Manfrè, V, Praprotnik, S, Hernandez-Molina, G, Bandeira, M, Rischmueller, M, Suzuki, Y, Solans-Laqué, R, Pasoto, S, Fugmann, C, Sanchez-Berna, I, Carubbi, F, Trevisani, VFM, Valim, V, Díaz, SM, Noia, BM, Fonseca-Aizpuru, E, Nakamura, H, Miguel, LD, Vázquez, M, Montalvo, MA, Policarpo-Torres, G, De Miguel-Campo, B, Horváth, IF, Gattamelata, A, Vissink, A, Quartuccio, L, Kiliç, L, Perdan-Pirkmajer, K, da Costa, RP, Bartoloni, E, Fujisawa, Y, Ramos-Casals, M, Brito-Zerón, P

AUTOANTIBODY-COMBINED SIGNATURES DELINEATING IMMUNOLOGIC CLUSTERS RELATED TO HIGH SYSTEMIC ACTIVITY IN PATIENTS WITH SJÖGREN DISEASE

ANNALS OF THE RHEUMATIC DISEASES, 2025, 84 dx.doi.org/10.1136/annrheumdis-2025-eular.B3630

Medicina Interna

Flores-Chávez, A, Garcia, LTD, Szántó, A, Priori, R, Bootsma, H, Armagan, B, Manfrè, V, Praprotnik, S, Hernandez-Molina, G, Romao, VC, Gerli, R, Rischmueller, M, Suzuki, Y, Solans-Laque, R, Pasoto, S, Nordmark, G, Sanchez-Berna, I, Carubbi, F, Trevisani, VFM, Valim, V, Díaz, SM, Noia, BM, Fonseca-Aizpuru, E, Nakamura, H, Miguel, LD, Vázquez, M, Montalvo, MA, Policarpo-Torres, G, De Miguel-Campo, B, Horváth, IF, Gattamelata, A, Vissink, A, Quartuccio, L, Kilic, L, Perdan-Pirkmajer, K, Bandeira, M, Bartoloni, E, Downie-Doyle, S, Fujisawa, Y, Ramos-Casals, M, Brito-Zerón, P

SEX DISPARITIES IN THE PHENOTYPE AT DIAGNOSIS OF SJÖGREN DISEASE: A GENERATIVE AI-DRIVEN CHARACTERIZATION IN 17,416 PATIENTS

ANNALS OF THE RHEUMATIC DISEASES, 2025, 84 dx.doi.org/10.1136/annrheumdis-2025-eular.B3784

Medicina Interna

Brito-Zeron, P, Flores-Chávez, A, Feijoo-Masso, C, Policarpo-Torres, G, Torre, RGD, Escalante, B, Lopez-Dupla, JM, Soler-i-Ferrer, C, Fonseca-Aizpuru, E, González-García, A, Herranz-Pérez, JC, Morillo, SG, Alguacil, A, Marhuenda, AR, Bonet, M, Villalba-García, MV, Chamorro, AJ, De Miguel-Campo, B, Caparros, MGC, Montalvo, MA, Mayer-Fuentes, A, Ramos-Casals, M

SARCOIDOSIS AS A SYSTEMIC DISEASE: IDENTIFYING PATTERNS OF MULTIORGAN-SPECIFIC INVOLVEMENT AND EPIDEMIOLOGICAL PROFILING THROUGH GENERATIVE ARTIFICIAL INTELLIGENCE DRIVEN CLUSTERING

ANNALS OF THE RHEUMATIC DISEASES, 2025, 84 dx.doi.org/10.1136/annrheumdis-2025-eular.B2011

Medicina Interna

Mayer-Fuentes, A, Feijoo-Masso, C, Flores-Chávez, A, Policarpo-Torres, G, de la Torre, RG, Vallejo-Grijalba, J, Lopez-Dupla, JM, Soler-i-Ferrer, C, Fonseca-Aizpuru, E, González-García, A, Rouco-Esteves-Marques, R, Morillo, SG, Alguacil, A, Marhuenda, AR, Bonet, M, Villalba-García, MV, Chamorro, AJ, De Miguel-Campo, B, Caparros, MGC, Montalvo, MA, Ramos-Casals, M, Brito-Zerón, P

PREDICTORS OF MORTALITY IN SARCOIDOSIS: A NATIONWIDE COHORT STUDY FROM THE SARCOGEAS REGISTRY

ANNALS OF THE RHEUMATIC DISEASES, 2025, 84 dx.doi.org/10.1136/annrheumdis-2025-eular.B1107

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Proyectos competitivos

Medicina Interna

RBD Dimer recombinant protein vaccine against SARSCoV2

Codi oficial: 101046118 Data inicio:01/12/2021 Data fi: 31/08/2025 Investigador/a principal: RAFEL RAMOS BLANES, RAMON BRUGADA TERRADELLAS, ANTONI CASTRO GUARDIOLA Organisme finançador: EUROPEAN HEALTH AND DIGITAL EXECUTIVE AGENCY (HADEA)

Ofertas de trabajo

Occult cancer in patients with unprovoked venous thromboembolism: Rationale, design, and methods of the VaLRIETEs study and the SOME-RIETE trial.

Identification of phenotypes and predictors for dyspnea, echocardiographic probability of pulmonary hypertension, and confirmed CTEPH in patients with acute pulmonary embolism: Analysis of two large patient cohorts.

FREQUENCY AND PATTERNS OF COEXISTENCE OF OTHER SYSTEMIC AUTOIMMUNE DISEASES IN PATIENTS WITH MIXED CONNECTIVE TISSUE DISEASE: IDENTIFICATION OF CLINICALLY RELEVANT SUBTYPES THROUGH CLUSTER ANALYSIS

A NOVEL AGE-DEFINED PHENOTYPIC LANDSCAPE IN MIXED CONNECTIVE TISSUE DISEASE: DISTINCT CLINICAL AND IMMUNOLOGICAL PATTERNS AT DIAGNOSIS IN 211 SPANISH PATIENTS

A machine learning approach to identify patients at risk for long-term consequences after pulmonary embolism.

External validation of the VTE-PREDICT score for predicting recurrence and bleeding in venous thromboembolism: Results from the RIETE registry.

AUTOANTIBODY-COMBINED SIGNATURES DELINEATING IMMUNOLOGIC CLUSTERS RELATED TO HIGH SYSTEMIC ACTIVITY IN PATIENTS WITH SJÖGREN DISEASE

SEX DISPARITIES IN THE PHENOTYPE AT DIAGNOSIS OF SJÖGREN DISEASE: A GENERATIVE AI-DRIVEN CHARACTERIZATION IN 17,416 PATIENTS

SARCOIDOSIS AS A SYSTEMIC DISEASE: IDENTIFYING PATTERNS OF MULTIORGAN-SPECIFIC INVOLVEMENT AND EPIDEMIOLOGICAL PROFILING THROUGH GENERATIVE ARTIFICIAL INTELLIGENCE DRIVEN CLUSTERING

PREDICTORS OF MORTALITY IN SARCOIDOSIS: A NATIONWIDE COHORT STUDY FROM THE SARCOGEAS REGISTRY

Equipo

Jefe de Grupo - R4

Investigadores/as Pre-doctorales – R1

Investigadores/as Colaboradores/as

Conoce el IDIBGI!