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A centre dedicated to the study of diseases associated with sudden death.

The CGC's research aims to improve knowledge of the associated factors and basic mechanisms that cause cardiovascular disease and sudden death and improve the tools for its diagnostic, prevention, and treatment.

This scientific area is divided into a clinical research area and a basic research area.

CLINICAL RESEARCH: The clinical research program takes advantage of the collaboration of hospitals and health centres to study risk factors, possible treatments, and prevention methods.

BASIC RESEARCH: Studies aimed at better understanding the biological bases of diseases associated with sudden death. The laboratory participates in different projects to understand the physio pathological basis of sudden death in six major aspects: Genetics, epigenetics, histology, electrophysiology, membrane trafficking and proteomics.

Visit Gencardio Diagnostics' website

Main lines of research

Genetic and molecular bases of sudden cardiac death.

Strategic objectives
  • Promote research, teaching and health care quality in the field of heart disease, especially in those that can cause arrhythmias and sudden death
  • Carry out a basic and clinical research program dedicated to cardiovascular disease.
  • The research program is based on the synergy provided by the different specialisms within the group.
  • Provide high-level medical assistance thanks to the incorporation of genetic technology into current methods of diagnosis and treatment.
  • Genetic results allow complementing clinical tests, often insufficient to reach a diagnosis, and customizing treatment options.
  • Develop new genetic tools that improve the diagnosis of patients at risk of cardiovascular disease. Main lines of research
  • Genetic and molecular bases of sudden cardiac death.
Publications
Neves R, Bains S, Bos JM, van der Werf C, Bergeman AT, Peltenburg P, Blom NA, Sanatani S, Swan H, Probst V, Kannankeril PJ, Skinner JR, Brugada R, Robyns T, Borggrefe M, Shimizu W, Kammeraad JAE, Krahn AD, Wilde AAM, Ackerman MJ

International Multicenter Cohort Study on Beta-Blocker-Free Treatment Strategies for Catecholaminergic Polymorphic Ventricular Tachycardia Patients.

JACC-CLINICAL ELECTROPHYSIOLOGY, 2025, 11, 270-278 dx.doi.org/10.1016/j.jacep.2024.10.005
Grassi, S, Vaiano, F, Dimitrova, A, Vullo, C, Croce, EB, Rossi, R, Arena, V, Rossi, SS, Campuzano, O, Brugada, R, Oliva, A

Fatal intoxications and inherited cardiac disorders in the young: where to draw the line?

INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2025, 139, 1081-1091 dx.doi.org/10.1007/s00414-025-03439-9
Liu H, Jiang Z, Shen Y, Shao Y, Su Y, Wang D, Brugada R, Hong K

Topological Distribution of KCNH2 Variants and Genotype-Phenotype Relationship in Patients With Long QT Syndrome.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2025, 48, 351-362 dx.doi.org/10.1111/pace.15145
Sabaté-Ortega, J, Teixidor-Vilà, E, Sais, E, Hernandez-Martínez, A, Montañés-Ferrer, C, Coma, N, Polonio-Alcalá, E, Pineda, V, Bosch-Barrera, J

Cardiovascular toxicity induced by immunotherapy in non-small cell lung cancer: a systematic review and meta-analysis of observational studies

Frontiers in oncology, 2025, 15 dx.doi.org/10.3389/fonc.2025.1528950
Tadros R, Jordà P

Acquired and Genetic Causes of Heart Disease Can Co-Exist in a Single Patient.

Jacc. Case Reports, 2025, 30, 103363-103363 dx.doi.org/10.1016/j.jaccas.2025.103363
Salinas, GLA, León, AM, Cano, DA, Esteban-Fernández, A, Flórez, JMV, Díaz, SD, Górriz-Magaña, J, Delgado, GD, González-Manzanares, R, Caravaca-Pérez, P, Pastor-Pérez, FJ, Valdivieso-Moré, S, Quiles, J, Ponz, I, Escolar, V, Lincango, EOB, Báez-Ferrer, N, Gallego, G, Almenar, L, de la Varga, LG, Codina, P, Mayoral, AR, Fort, A, Lozano, MJP, González-Calle, D, Gómez-Otero, I, Mosteiro, CS, Cobo, M, Piqueras-Flores, J, Bonanad, C, Huerta, A, Vallverdú, MF, Díez-Villanueva, P

Clinical utility and safety of finerenone in patients with heart failure: Rationale and design of FINE registry

ESC heart failure, 2025 dx.doi.org/10.1002/ehf2.15260
Ramos M, Enguita FJ, Bonet F, Ayala R, Gómez-Pavón FJ, Campuzano O, Toro R, Quezada-Feijoó M

MicroRNA-143-3p and miR-452-5p: A Fingerprint for the Diagnosis of Aortic Stenosis in the Geriatric Population.

Biomedicines, 2025, 13 dx.doi.org/10.3390/biomedicines13030671
Campuzano O, Sarquella-Brugada G, Toro R

MicroRNAs unlock the mystery of arrhythmogenic cardiomyopathy.

POLISH HEART JOURNAL-KARDIOLOGIA POLSKA, 2025, 83, 413-414 dx.doi.org/10.33963/v.phj.105101
Martínez-Barrios E, Greco A, Cesar S, Díez-López C, Cruzalegui J, Díez-Escuté N, Cerralbo P, Chipa F, Zschaeck I, Grassi S, Oliva A, Balderrábano N, Toro R, Sarquella-Brugada G, Campuzano O

Appropriate time interval to update ambiguous genetic diagnosis in inherited arrhythmogenic syndromes.

Iscience, 2025, 28, 112300-112300 dx.doi.org/10.1016/j.isci.2025.112300
Narasimhan B, Na J, Monasky MM, Brugada R, Miyasaka Y, Brugada J, Brugada P, Krittanawong C

Brugada syndrome.

Nature Reviews Disease Primers, 2025, 11, 38-38 dx.doi.org/10.1038/s41572-025-00622-5
Competitive projects
Cardiovascular Genetics

Variabilidad fenotípica en la Miocardiopatía Arritmogénica: De los mecanismos moleculares a la práctica clínica

Codi oficial: PI22/00422 Start date:01/01/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS, MIREIA ALCALDE MASEGÚ Organisme finançador: INSTITUTO DE SALUD CARLOS III
Cardiovascular Genetics

Implementció de la segona fase del programa Pm05 "Girona, territori cardioprotegit" - Isabel Ramió / Manjhot

Codi oficial: Girona, territori cardioprotegit Start date:01/07/2022 Data fi: 31/10/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: DIPUTACIO DE GIRONA
Cardiovascular Genetics

Ajuda de personal Suport als grups PERIS - Genètica Cardiovascular

Codi oficial: SLT028/23/000317 Start date:01/08/2023 Data fi: 31/12/2025 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: GENERALITAT DE CATALUNYA
Cardiovascular Genetics

Estudio prospectivo, aleatorizado, multicéntrico, abierto, guiado por eventos, para evaluar la no inferioridad de una estrategia personalizada de precisión para la prevención de la muerte súbita en pacientes con miocardiopatía dilatada no isquémica

Codi oficial: Estudi CIBER-SPANISH I Start date:15/01/2024 Data fi: 15/05/2028 Investigador/a principal: RAMON BRUGADA TERRADELLAS
Cardiovascular Genetics

Ayuda de personal PFIS

Codi oficial: FI23/00047 Start date:01/02/2024 Data fi: 31/01/2028 Investigador/a principal: RAMON BRUGADA TERRADELLAS, ESTEL ARTIGAS MELEIRO Organisme finançador: INSTITUTO DE SALUD CARLOS III
Cardiovascular Genetics

Genetic predisposition to myocardial infarction in the young

Codi oficial: CI24-10110 Start date:01/12/2024 Data fi: 30/11/2026 Investigador/a principal: RAMON BRUGADA TERRADELLAS Organisme finançador: FUNDACIÓN BANCARIA LA CAIXA
Cardiovascular Genetics

Predisposición genética al infarto de miocardio en jovenes

Codi oficial: PI24/00164 Start date:01/01/2025 Data fi: 31/12/2027 Investigador/a principal: MÓNICA COLL VIDAL Organisme finançador: INSTITUTO DE SALUD CARLOS III
Cardiovascular Genetics

Impacto de un programa estructurado de ejercicio físico y control de factores de riesgo cardiovasculares en prevención primaria de cardiotoxicidad en pacientes con cáncer de mama sometidos a tratamientos cardiotóxicos: Estudio PREV

Codi oficial: Estudio PREV Start date:01/11/2021 Data fi: 31/12/2025 Investigador/a principal: ARANTXA ERASO URIÉN, SERGI MORAL TORRES Organisme finançador: FUNDACION MERCK SALUD
Cardiovascular Genetics

AI Scalable Solution for ST Myocardial Infarction

Codi oficial: 2023-SUD-1831 Start date:01/07/2023 Data fi: 31/12/2025 Investigador/a principal: JAIME ABOAL VIÑAS Organisme finançador: EUROPEAN HEALTH AND DIGITAL EXECUTIVE AGENCY (HADEA)
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